Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

TY - JOUR

T1 - Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data

T2 - an observational, multicohort, retrospective analysis

AU - LUNG SAFE Investigators and the ESICM Trials Group

AU - Maddali, Manoj V.

AU - Churpek, Matthew

AU - Pham, Tai

AU - Rezoagli, Emanuele

AU - Zhuo, Hanjing

AU - Zhao, Wendi

AU - He, June

AU - Delucchi, Kevin L.

AU - Wang, Chunxue

AU - Wickersham, Nancy

AU - McNeil, J. Brennan

AU - Jauregui, Alejandra

AU - Ke, Serena

AU - Vessel, Kathryn

AU - Gomez, Antonio

AU - Hendrickson, Carolyn M.

AU - Kangelaris, Kirsten N.

AU - Sarma, Aartik

AU - Leligdowicz, Aleksandra

AU - Liu, Kathleen D.

AU - Matthay, Michael A.

AU - Ware, Lorraine B.

AU - Laffey, John G.

AU - Bellani, Giacomo

AU - Calfee, Carolyn S.

AU - Sinha, Pratik

AU - Rios, Fernando

AU - Van Haren, Frank

AU - Sottiaux, T.

AU - Lora, Fredy S.

AU - Azevedo, Luciano C.

AU - Depuydt, P.

AU - Fan, Eddy

AU - Bugedo, Guillermo

AU - Qiu, Haibo

AU - Gonzalez, Marcos

AU - Silesky, Juan

AU - Cerny, Vladimir

AU - Nielsen, Jonas

AU - Jibaja, Manuel

AU - Pham, Tài

AU - Wrigge, Hermann

AU - Matamis, Dimitrios

AU - Ranero, Jorge Luis

AU - Hashemian, S. M.

AU - Amin, Pravin

AU - Clarkson, Kevin

AU - Kurahashi, Kiyoyasu

AU - Villagomez, Asisclo

AU - Zeggwagh, Amine Ali

N1 - Funding Information: This study was funded by the US National Institutes of Health (GM142992 to PS, HL140026 to CSC, and HL103836 and HL135849 to LBW) and the European Society of Intensive Care Medicine. We thank Fabiana Madotto (IRCCS Sesto San Giovanni: Sesto San Giovanni, Lombardia, Italy), James Anstey (University of California San Francisco, San Francisco, CA, USA), and Nader Najafi (University of California San Francisco) for their contributions to data collection, cleaning, and analysis. MC reports grants from the US National Institute on Drug Abuse (R01 DA051464), the US Department of Defense Peer Reviewed Medical Research Program (W81XWH-21-1-0009), the National Institute on Aging (R21 AG068720), grants from the National Institute of General Medical Sciences (R01 GM123193), grants from the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK126933), EarlySense (Tel Aviv, Israel), and the National Heart, Lung, and Blood Institute (NHLBI; R01 HL157262), outside the submitted work. AS reports grants from the NHLBI, during the conduct of the study. JGL reports grants from the European Society of Intensive Care Medicine, during the conduct of the study. We thank all patients and researchers who participated in the NHLBI ARDS Network trials (ALVEOLI, FACTT, and SAILS) from which data from this study were derived. We acknowledge the contributions of health-care providers and research staff who enabled the successful completion of these trials. In addition, we thank the contributions of the Biological Specimen and Data Repository Information Coordinating Center of the NHLBI that made the data and biological specimens available to do these studies. This manuscript was prepared using ALVEOLI, ARDSNET, and FACTT research materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center and does not necessarily reflect the opinions or views of the ALVEOLI, ARDSNET, FACTT, or NHLBI. Funding Information: This study was funded by the US National Institutes of Health (GM142992 to PS, HL140026 to CSC, and HL103836 and HL135849 to LBW) and the European Society of Intensive Care Medicine. We thank Fabiana Madotto (IRCCS Sesto San Giovanni: Sesto San Giovanni, Lombardia, Italy), James Anstey (University of California San Francisco, San Francisco, CA, USA), and Nader Najafi (University of California San Francisco) for their contributions to data collection, cleaning, and analysis. MC reports grants from the US National Institute on Drug Abuse (R01 DA051464), the US Department of Defense Peer Reviewed Medical Research Program (W81XWH-21-1-0009), the National Institute on Aging (R21 AG068720), grants from the National Institute of General Medical Sciences (R01 GM123193), grants from the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK126933), EarlySense (Tel Aviv, Israel), and the National Heart, Lung, and Blood Institute (NHLBI; R01 HL157262), outside the submitted work. AS reports grants from the NHLBI, during the conduct of the study. JGL reports grants from the European Society of Intensive Care Medicine, during the conduct of the study. We thank all patients and researchers who participated in the NHLBI ARDS Network trials (ALVEOLI, FACTT, and SAILS) from which data from this study were derived. We acknowledge the contributions of health-care providers and research staff who enabled the successful completion of these trials. In addition, we thank the contributions of the Biological Specimen and Data Repository Information Coordinating Center of the NHLBI that made the data and biological specimens available to do these studies. This manuscript was prepared using ALVEOLI, ARDSNET, and FACTT research materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center and does not necessarily reflect the opinions or views of the ALVEOLI, ARDSNET, FACTT, or NHLBI. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/4

Y1 - 2022/4

UR - http://www.scopus.com/inward/record.url?scp=85124466107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85124466107&partnerID=8YFLogxK

U2 - 10.1016/S2213-2600(21)00461-6

DO - 10.1016/S2213-2600(21)00461-6

M3 - Article

C2 - 35026177

AN - SCOPUS:85124466107

SN - 2213-2600

VL - 10

SP - 367

EP - 377

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

IS - 4

ER -