@article{af9b53d687814c639bede30b5e9c6684,
title = "Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis",
author = "{LUNG SAFE Investigators and the ESICM Trials Group} and Maddali, {Manoj V.} and Matthew Churpek and Tai Pham and Emanuele Rezoagli and Hanjing Zhuo and Wendi Zhao and June He and Delucchi, {Kevin L.} and Chunxue Wang and Nancy Wickersham and McNeil, {J. Brennan} and Alejandra Jauregui and Serena Ke and Kathryn Vessel and Antonio Gomez and Hendrickson, {Carolyn M.} and Kangelaris, {Kirsten N.} and Aartik Sarma and Aleksandra Leligdowicz and Liu, {Kathleen D.} and Matthay, {Michael A.} and Ware, {Lorraine B.} and Laffey, {John G.} and Giacomo Bellani and Calfee, {Carolyn S.} and Pratik Sinha and Fernando Rios and {Van Haren}, Frank and T. Sottiaux and Lora, {Fredy S.} and Azevedo, {Luciano C.} and P. Depuydt and Eddy Fan and Guillermo Bugedo and Haibo Qiu and Marcos Gonzalez and Juan Silesky and Vladimir Cerny and Jonas Nielsen and Manuel Jibaja and T{\`a}i Pham and Hermann Wrigge and Dimitrios Matamis and Ranero, {Jorge Luis} and Hashemian, {S. M.} and Pravin Amin and Kevin Clarkson and Kiyoyasu Kurahashi and Asisclo Villagomez and Zeggwagh, {Amine Ali}",
note = "Funding Information: This study was funded by the US National Institutes of Health (GM142992 to PS, HL140026 to CSC, and HL103836 and HL135849 to LBW) and the European Society of Intensive Care Medicine. We thank Fabiana Madotto (IRCCS Sesto San Giovanni: Sesto San Giovanni, Lombardia, Italy), James Anstey (University of California San Francisco, San Francisco, CA, USA), and Nader Najafi (University of California San Francisco) for their contributions to data collection, cleaning, and analysis. MC reports grants from the US National Institute on Drug Abuse (R01 DA051464), the US Department of Defense Peer Reviewed Medical Research Program (W81XWH-21-1-0009), the National Institute on Aging (R21 AG068720), grants from the National Institute of General Medical Sciences (R01 GM123193), grants from the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK126933), EarlySense (Tel Aviv, Israel), and the National Heart, Lung, and Blood Institute (NHLBI; R01 HL157262), outside the submitted work. AS reports grants from the NHLBI, during the conduct of the study. JGL reports grants from the European Society of Intensive Care Medicine, during the conduct of the study. We thank all patients and researchers who participated in the NHLBI ARDS Network trials (ALVEOLI, FACTT, and SAILS) from which data from this study were derived. We acknowledge the contributions of health-care providers and research staff who enabled the successful completion of these trials. In addition, we thank the contributions of the Biological Specimen and Data Repository Information Coordinating Center of the NHLBI that made the data and biological specimens available to do these studies. This manuscript was prepared using ALVEOLI, ARDSNET, and FACTT research materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center and does not necessarily reflect the opinions or views of the ALVEOLI, ARDSNET, FACTT, or NHLBI. Funding Information: This study was funded by the US National Institutes of Health (GM142992 to PS, HL140026 to CSC, and HL103836 and HL135849 to LBW) and the European Society of Intensive Care Medicine. We thank Fabiana Madotto (IRCCS Sesto San Giovanni: Sesto San Giovanni, Lombardia, Italy), James Anstey (University of California San Francisco, San Francisco, CA, USA), and Nader Najafi (University of California San Francisco) for their contributions to data collection, cleaning, and analysis. MC reports grants from the US National Institute on Drug Abuse (R01 DA051464), the US Department of Defense Peer Reviewed Medical Research Program (W81XWH-21-1-0009), the National Institute on Aging (R21 AG068720), grants from the National Institute of General Medical Sciences (R01 GM123193), grants from the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK126933), EarlySense (Tel Aviv, Israel), and the National Heart, Lung, and Blood Institute (NHLBI; R01 HL157262), outside the submitted work. AS reports grants from the NHLBI, during the conduct of the study. JGL reports grants from the European Society of Intensive Care Medicine, during the conduct of the study. We thank all patients and researchers who participated in the NHLBI ARDS Network trials (ALVEOLI, FACTT, and SAILS) from which data from this study were derived. We acknowledge the contributions of health-care providers and research staff who enabled the successful completion of these trials. In addition, we thank the contributions of the Biological Specimen and Data Repository Information Coordinating Center of the NHLBI that made the data and biological specimens available to do these studies. This manuscript was prepared using ALVEOLI, ARDSNET, and FACTT research materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center and does not necessarily reflect the opinions or views of the ALVEOLI, ARDSNET, FACTT, or NHLBI. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = apr,
doi = "10.1016/S2213-2600(21)00461-6",
language = "English",
volume = "10",
pages = "367--377",
journal = "The Lancet Respiratory Medicine",
issn = "2213-2600",
publisher = "Elsevier Limited",
number = "4",
}