Potent dialkyl substrate-product analogue inhibitors and inactivators of α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis by rational design

Keyphrases

• Active Sites 25%
• Acyl-CoA 25%
• Alkyl Chain Length 25%
• Biological Mechanisms 25%
• Branched-chain Fatty Acids 25%
• Coenzyme A 100%
• Competitive Inhibition 25%
• Disubstituted 50%
• Enzyme Inhibitors 25%
• Epimerase 50%
• Epimerization 25%
• Human Enzymes 25%
• Inactivator 100%
• Inhibition Constant 25%
• Metabolism 25%
• Model Enzyme 25%
• Mycobacterium Tuberculosis (M. tb) 100%
• Pharmaceutical Agents 25%
• Potent Inhibitor 25%
• Prostate Cancer 25%
• Racemase 100%
• Rational Design 100%
• Rationally Designed 25%
• Substrate-product Analogues 100%
• Therapeutic Agents 25%

Biochemistry, Genetics and Molecular Biology

• Active Site 50%
• Acyl-CoA 50%
• Coenzyme A 100%
• Competitive Inhibition 50%
• Enzyme 50%
• Enzyme Inhibitor 50%
• Enzyme Models 50%
• Epimerization 50%
• Isomerase 50%
• Metabolic Pathway 50%
• Mycobacterium Tuberculosis 100%
• Substrate Concentration 50%