Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

Sumanta Garai; Pushkar M. Kulkarni; Peter C. Schaffer; Luciana M. Leo; Asher L. Brandt; Ayat Zagzoog; Tallan Black; Xiaoyan Lin; Dow P. Hurst; David R. Janero; Mary E. Abood; Anaelle Zimmowitch; Alex Straiker; Roger G. Pertwee; Melanie Kelly; Anna Maria Szczesniak; Eileen M. Denovan-Wright; Ken Mackie; Andrea G. Hohmann; Patricia H. Reggio; Robert B. Laprairie; Ganesh A. Thakur

doi:10.1021/acs.jmedchem.9b01142

Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

Sumanta Garai, Pushkar M. Kulkarni, Peter C. Schaffer, Luciana M. Leo, Asher L. Brandt, Ayat Zagzoog, Tallan Black, Xiaoyan Lin, Dow P. Hurst, David R. Janero, Mary E. Abood, Anaelle Zimmowitch, Alex Straiker, Roger G. Pertwee, Melanie Kelly, Anna Maria Szczesniak, Eileen M. Denovan-Wright, Ken Mackie, Andrea G. Hohmann, Patricia H. ReggioRobert B. Laprairie, Ganesh A. Thakur

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Original language	English
Pages (from-to)	542-568
Number of pages	27
Journal	Journal of Medicinal Chemistry
Volume	63
Issue number	2
DOIs	https://doi.org/10.1021/acs.jmedchem.9b01142
Publication status	Published - Jan 23 2020
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

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10.1021/acs.jmedchem.9b01142

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Garai, S., Kulkarni, P. M., Schaffer, P. C., Leo, L. M., Brandt, A. L., Zagzoog, A., Black, T., Lin, X., Hurst, D. P., Janero, D. R., Abood, M. E., Zimmowitch, A., Straiker, A., Pertwee, R. G., Kelly, M., Szczesniak, A. M., Denovan-Wright, E. M., Mackie, K., Hohmann, A. G., ... Thakur, G. A. (2020). Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry, 63(2), 542-568. https://doi.org/10.1021/acs.jmedchem.9b01142

Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators. / Garai, Sumanta; Kulkarni, Pushkar M.; Schaffer, Peter C. et al.
In: Journal of Medicinal Chemistry, Vol. 63, No. 2, 23.01.2020, p. 542-568.

Research output: Contribution to journal › Article › peer-review

Garai, S, Kulkarni, PM, Schaffer, PC, Leo, LM, Brandt, AL, Zagzoog, A, Black, T, Lin, X, Hurst, DP, Janero, DR, Abood, ME, Zimmowitch, A, Straiker, A, Pertwee, RG, Kelly, M, Szczesniak, AM, Denovan-Wright, EM, Mackie, K, Hohmann, AG, Reggio, PH, Laprairie, RB & Thakur, GA 2020, 'Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators', Journal of Medicinal Chemistry, vol. 63, no. 2, pp. 542-568. https://doi.org/10.1021/acs.jmedchem.9b01142

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author = "Sumanta Garai and Kulkarni, {Pushkar M.} and Schaffer, {Peter C.} and Leo, {Luciana M.} and Brandt, {Asher L.} and Ayat Zagzoog and Tallan Black and Xiaoyan Lin and Hurst, {Dow P.} and Janero, {David R.} and Abood, {Mary E.} and Anaelle Zimmowitch and Alex Straiker and Pertwee, {Roger G.} and Melanie Kelly and Szczesniak, {Anna Maria} and Denovan-Wright, {Eileen M.} and Ken Mackie and Hohmann, {Andrea G.} and Reggio, {Patricia H.} and Laprairie, {Robert B.} and Thakur, {Ganesh A.}",

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doi = "10.1021/acs.jmedchem.9b01142",

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AU - Janero, David R.

AU - Abood, Mary E.

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Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators

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