Would the recommended dose have been different using novel dose-finding designs? Comparing dose-finding designs in published trials

Keyphrases

• Dose-finding Design 100%
• Recommended Dose 100%
• Maximum Tolerated Dose 100%
• Novel Design 83%
• Dose-finding Trial 50%
• Simulation Study 50%
• 3 + 3 Design 50%
• Continual Reassessment Method 33%
• Dose Level 33%
• Toxicity Data 33%
• Model-based Design 16%
• Dose Escalation 16%
• Continued Use 16%
• Two-dose 16%
• Patient Samples 16%
• Patient Allocation 16%
• Design Complexity 16%
• 3-design 16%
• Oncology Trials 16%
• Suboptimal Dose 16%
• Bayesian Optimal Interval Design 16%
• Bayesian Optimal Interval 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Maximum Tolerated Dose 100%