Synthesis of α-Deoxymono and Difluorohexopyranosyl 1-Phosphates and Kinetic Evaluation with Thymidylyl- and Guanidylyltransferases

Keyphrases

• Glucopyranosyl 66%
• Difluoro 66%
• Promiscuity 33%
• Linear Free Energy Correlations 33%
• 6-bisphosphate 33%
• Hexose 33%
• NMR Titration 33%
• 19F NMR 33%
• 31P NMR 33%
• Titration Experiment 33%
• Isosteric 33%
• Substrate Promiscuity 33%

Chemistry

• 19F NMR Spectroscopy 50%
• Enzymatic Reaction 50%
• Hexose 50%
• Phosphorus-31 Magnetic Resonance Spectroscopy 50%
• Substrate Specificity 50%

Biochemistry, Genetics and Molecular Biology

• Hexose 100%
• Nucleophilicity 100%