@article{ac359100478c4f86bc6d3a7a3d1d48de,
title = "Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking",
author = "Langelaan, {David N.} and Tyler Reddy and Banks, {Aaron W.} and Graham Dellaire and Dupr{\'e}, {Denis J.} and Rainey, {Jan K.}",
note = "Funding Information: This research was supported by Canadian Institutes of Health Research (CIHR) Operating Grants to JKR ( MOP-111138 and ROP-91807 ) and GD ( MOP-84260 ) and by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant to DJD ( RGPIN/355310-2008 ). ROP-91807 was partnered through the Nova Scotia Health Research Foundation and Dalhousie University . DNL was the recipient of a Canada Graduate Scholarship (CGS) from NSERC ; TR was previously supported by an NSERC CGS and a Killam Predoctoral Scholarship and is currently supported by a CIHR Postdoctoral Fellowship ; AWB was the recipient of a CGS from the CIHR and a Killam Predoctoral Scholarship; GD, DJD and JKR are supported by CIHR New Investigator Awards ; and, GD is a Senior Scientist of the Beatrice Hunter Cancer Research Institute and the Cameron Research Scientist of the Dalhousie University Cancer Research Program. Funding Information: NMR experiments were recorded (1) with support from Dr. Tara Sprules at the Qu{\'e}bec/Eastern Canada High Field NMR Facility, supported by NSERC, the Canada Foundation for Innovation (CFI), the Qu{\'e}bec minist{\`e}re de la recherche en science et technologie, and McGill University; and, (2) at the NMR 3 Facility, supported by Dalhousie University, using the 700 MHz housed at the National Research Council of Canada's Institute for Marine Biosciences (NRC-IMB) and a He-cooled probe funded by an Atlantic Canada Opportunities Agency Grant to Dalhousie University. Simulations were performed using resources at Dalhousie University and, predominantly, at the Structural Bioinformatics & Computational Biochemistry Unit, Oxford, U.K. Grants from NSERC, the Dalhousie Medical Research Foundation and the CFI provided equipment essential for this work. We thank Dr. Philip Fowler (SBCB, Oxford, UK) for helpful advice regarding simulations. Finally, we are grateful to Dr. Devanand M. Pinto (NRC-IMB) for providing MALDI-MS access. ",
year = "2013",
month = jun,
doi = "10.1016/j.bbamem.2013.02.005",
language = "English",
volume = "1828",
pages = "1471--1483",
journal = "Biochimica et Biophysica Acta - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "6",
}
