Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Morgan D. Fullerton; Sandra Galic; Katarina Marcinko; Sarah Sikkema; Thomas Pulinilkunnil; Zhi Ping Chen; Hayley M. O'Neill; Rebecca J. Ford; Rengasamy Palanivel; Matthew O'Brien; D. Grahame Hardie; S. Lance MacAulay; Jonathan D. Schertzer; Jason R.B. Dyck; Bryce J. Van Denderen; Bruce E. Kemp; Gregory R. Steinberg

doi:10.1038/nm.3372

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Morgan D. Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi Ping Chen, Hayley M. O'Neill, Rebecca J. Ford, Rengasamy Palanivel, Matthew O'Brien, D. Grahame Hardie, S. Lance MacAulay, Jonathan D. Schertzer, Jason R.B. Dyck, Bryce J. Van Denderen, Bruce E. Kemp, Gregory R. Steinberg

科研成果: 期刊稿件 › 文章 › 同行评审

700 引用（Scopus）

源语言	英语
页（从-至）	1649-1654
页数	6
期刊	Nature Medicine
卷	19
期	12
DOI	https://doi.org/10.1038/nm.3372
出版状态	已出版 - 12月 2013
已对外发布	是

!!!ASJC Scopus Subject Areas

一般生物化学、遗传与分子生物学

联合国可持续发展目标

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10.1038/nm.3372

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Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z. P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., Hardie, D. G., MacAulay, S. L., Schertzer, J. D., Dyck, J. R. B., Van Denderen, B. J., Kemp, B. E., & Steinberg, G. R. (2013). Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nature Medicine, 19(12), 1649-1654. https://doi.org/10.1038/nm.3372

Fullerton, MD, Galic, S, Marcinko, K, Sikkema, S, Pulinilkunnil, T, Chen, ZP, O'Neill, HM, Ford, RJ, Palanivel, R, O'Brien, M, Hardie, DG, MacAulay, SL, Schertzer, JD, Dyck, JRB, Van Denderen, BJ, Kemp, BE & Steinberg, GR 2013, 'Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin', Nature Medicine, 卷 19, 号码 12, 页码 1649-1654. https://doi.org/10.1038/nm.3372

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title = "Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin",

author = "Fullerton, {Morgan D.} and Sandra Galic and Katarina Marcinko and Sarah Sikkema and Thomas Pulinilkunnil and Chen, {Zhi Ping} and O'Neill, {Hayley M.} and Ford, {Rebecca J.} and Rengasamy Palanivel and Matthew O'Brien and Hardie, {D. Grahame} and MacAulay, {S. Lance} and Schertzer, {Jonathan D.} and Dyck, {Jason R.B.} and {Van Denderen}, {Bryce J.} and Kemp, {Bruce E.} and Steinberg, {Gregory R.}",

note = "Funding Information: We thank C. Saab from the McMaster Centre for Translational Imaging for completing the computed tomography analysis and S. Stypa and E. Day for technical assistance. This study was supported by grants and fellowships from the Australian Research Council and the Commonwealth Scientific and Industrial Research Organisation (B.E.K.), the Australian National Health and Medical Research Council (B.E.K., B.J.v.D. and G.R.S.), the Canadian Diabetes Association (G.R.S., J.R.B.D. and J.D.S.) and the Canadian Institutes of Health Research (CIHR) (G.R.S. and J.R.B.D.) and was supported in part by the Victorian Government Operational Infrastructure Support Program (B.E.K.) and the Canadian Foundation for Innovation (G.R.S.). M.D.F. is supported by a CIHR Banting Postdoctoral Fellowship, J.D.S. is supported by a Canadian Diabetes Association Scholar Award and G.R.S. holds a Canada Research Chair in Metabolism and Obesity.",

year = "2013",

month = dec,

doi = "10.1038/nm.3372",

language = "English",

volume = "19",

pages = "1649--1654",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "12",

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T1 - Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

AU - Fullerton, Morgan D.

AU - Galic, Sandra

AU - Marcinko, Katarina

AU - Sikkema, Sarah

AU - Pulinilkunnil, Thomas

AU - Chen, Zhi Ping

AU - O'Neill, Hayley M.

AU - Ford, Rebecca J.

AU - Palanivel, Rengasamy

AU - O'Brien, Matthew

AU - Hardie, D. Grahame

AU - MacAulay, S. Lance

AU - Schertzer, Jonathan D.

AU - Dyck, Jason R.B.

AU - Van Denderen, Bryce J.

AU - Kemp, Bruce E.

AU - Steinberg, Gregory R.

N1 - Funding Information: We thank C. Saab from the McMaster Centre for Translational Imaging for completing the computed tomography analysis and S. Stypa and E. Day for technical assistance. This study was supported by grants and fellowships from the Australian Research Council and the Commonwealth Scientific and Industrial Research Organisation (B.E.K.), the Australian National Health and Medical Research Council (B.E.K., B.J.v.D. and G.R.S.), the Canadian Diabetes Association (G.R.S., J.R.B.D. and J.D.S.) and the Canadian Institutes of Health Research (CIHR) (G.R.S. and J.R.B.D.) and was supported in part by the Victorian Government Operational Infrastructure Support Program (B.E.K.) and the Canadian Foundation for Innovation (G.R.S.). M.D.F. is supported by a CIHR Banting Postdoctoral Fellowship, J.D.S. is supported by a Canadian Diabetes Association Scholar Award and G.R.S. holds a Canada Research Chair in Metabolism and Obesity.

PY - 2013/12

Y1 - 2013/12

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U2 - 10.1038/nm.3372

DO - 10.1038/nm.3372

M3 - Article

AN - SCOPUS:84889887123

SN - 1078-8956

VL - 19

SP - 1649

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JO - Nature Medicine

JF - Nature Medicine

IS - 12

ER -

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

!!!ASJC Scopus Subject Areas

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