Resting State MRI Amplitude of Low Frequency Fluctuations Associated With Suicidal Ideation in Bipolar Depression

TY - JOUR

T1 - Resting State MRI Amplitude of Low Frequency Fluctuations Associated With Suicidal Ideation in Bipolar Depression

AU - Lan, Martin J.

AU - Pantazatos, Spiro P.

AU - Todd Ogden, R.

AU - Rubin-Falcone, Harry

AU - Hellerstein, David

AU - McGrath, Patrick J.

AU - John Mann, J.

N1 - Funding Information: Submitted: April 21, 2021; accepted November 9, 8. Zuo XN, Di Martino A, Kelly C, et al. The 23. Winkler AM, Ridgway GR, Webster MA, et al. 2021. oscillating brain: complex and reliable. Permutation inference for the general linear Publishedonline:March 30, 2022. Neuroimage. 2010;49(2):1432–1445.PubMed CrossRef model. Neuroimage. 2014;92:381–397.PubMed CrossRef 9. Lan MJ, Rizk MM, Pantazatos SP, et al. Resting-Lett TA, Kennedy JL, Radhu N, et al. Prefrontal Potential conflicts of interest:Dr Mann receives state amplitude of low-frequency fluctuation white matter structure mediates the influence royalties from the Research Foundation for Mental is associated with suicidal ideation. Depress of GAD1 on working memory. Hygiene for commercial use oftheC-SSRS. Drs Lan, Anxiety. 2019;36(5):433–441.PubMed CrossRef Neuropsychopharmacology. Pantazatos, Ogden, Hellerstein, and McGrath and 10. Wagner G, Li M, Sacchet MD, et al. Functional 2016;41(9):2224–2231.PubMed CrossRef Mr Rubin-Falcone have no conflicts of interest. network alterations differently associated Anderson MJ, Robinson J. Permutation tests for Funding/support:The study was supported with suicidal ideas and acts in depressed linear models. Aust N Z J Stat. 2001;43(1):75–88. CrossRef byNationalInstituteofMentalHealthgrant patients: an indirect support to the transition Smith SM, Nichols TE. Threshold-free cluster K23MH105688,anIndependentMedicalEducation model. Transl Psychiatry. 2021;11(1):100.PubMed CrossRef enhancement: addressing problems of Grant from Sunovion Pharmaceuticals, and the 11. Pompili M, Gonda X, Serafini G, et al. smoothing, threshold dependence and AmericanFoundationforSuicidePrevention(AFSP) Epidemiology of suicide in bipolar disorders: a localisation in cluster inference. Neuroimage. SRG-0-102-16 (awarded to Dr Pantazatos). systematic review of the literature. Bipolar 2009;44(1):83–98.PubMed CrossRef Role of the sponsor: The funding agencies had no Disord. 2013;15(5):457–490.PubMed CrossRef Cao J, Chen X, Chen J, et al. Resting-state role in the writing or editing ofthe manuscript or in 12. The World Health Report 2002: Reducing Risks, functional MRI of abnormal baseline brain the design or conduct ofthe study. Promoting Healthy Life. Geneva, Switzerland: activity in young depressed patients with and Acknowledgements:The authors thank Eric World Health Organization; 2002. without suicidal behavior. J Affect Disord. Hauser,BA, for help organizing the data and 13. McIntyre RS, Berk M, Brietzke E, et al. Bipolar 2016;205:252–263.PubMed CrossRef preparingfiguresandVinushiniArunagiri,BA; disorders. Lancet. 2020;396(10265):1841–1856.PubMed CrossRef Tian S, Zhu R, Chattun MR, et al. Temporal Michelle Parris, BA; and Allison Metts, BA, for their 14. Rush AJ, Trivedi MH, Ibrahim HM, et al. The dynamics alterations of spontaneous neuronal efforts in coordinating the project. None ofthem 16-Item Quick Inventory of Depressive activity in anterior cingulate cortex predict have conflicts of interest to declare, and they all Symptomatology (QIDS), clinician rating suicidal risk in bipolar II patients. Brain Imaging had affiliations with the Department of Psychiatry, (QIDS-C), and self-report (QIDS-SR): a Behav. 2021;15(5):2481–2491.PubMed CrossRef psychometric evaluation in patients with Gong J, Chen G, Zhou M, et al. Characteristics Vagelos College of Physicians and Surgeons at chronic major depression. Biol Psychiatry. of temporal dynamics of intrinsic brain activity Columbia University,NewYork, NewYork. We 2003;54(5):573–583.PubMed CrossRef in unmedicated bipolar disorder with alsothankalloftheresearchparticipantsfortheir 15. Hamilton M. A rating scale for depression. suicidality. Aust N Z J Psychiatry. contributions. J Neurol Neurosurg Psychiatry. 2020;54(11):1115–1124.PubMed CrossRef 1960;23(1):56–62.PubMed CrossRef Fan T, Wu X, Yao L, et al. Abnormal baseline 16. Lan MJ, Rubin-Falcone H, Motiwala F, et al. brain activity in suicidal and non-suicidal White matter tract integrity is associated with patients with major depressive disorder. McClay MM, O’Connor SS, Groh BN, et al. Denial antidepressant response to lurasidone in NeurosciLett. 2013;534:35–40.PubMedCrossRef ofsuicideattemptamonghospitalized bipolar depression. Bipolar Disord. Chase HW, Segreti AM, Keller TA, et al. survivors of a self-inflicted gunshot wound. 2017;19(6):444–449.PubMed CrossRef Alterations of functional connectivity and PsychiatrServ.2018;69(6):657–663.PubMedCrossRef 17. Montgomery SA, Asberg M. A new depression intrinsic activity within the cingulate cortex of Apter A, Plutchik R, Sevy S, et al. Defense scale designed to be sensitive to change. Br J suicidal ideators. J Affect Disord. mechanisms in risk of suicide and risk of Psychiatry. 1979;134(4):382–389.PubMed CrossRef 2017;212:78–85.PubMed CrossRef violence.Am J Psychiatry. 18. Lan MJ, Zanderigo F, Pantazatos SP, et al. Du L, Zeng J, Liu H, et al. Fronto-limbic 1989;146(8):1027–1031.PubMedCrossRef Serotonin 1A receptor binding of [11C]CUMI-disconnection in depressed patients with WHO. World Heath Statistics 2021. Monitoring 101 in bipolar depression quantified using suicidal ideation: a resting-state functional Health for the SDGs. WHO website. https:// positron emission tomography: relationship connectivity study. J Affect Disord. apps.who.int/iris/bitstream/hand to psychopathology and antidepressant 2017;215:213–217.PubMed CrossRef le/10665/342703/9789240027053-eng.pdf. response. (online ahead of print) Int J Wei S, Chang M, Zhang R, et al. Amygdala 2021. Accessed March 9, 2022. Neuropsychopharmacol. 2022;pyac001.PubMed CrossRef functional connectivity in female patients with Mann JJ, Apter A, Bertolote J, et al. Suicide 19. Craddock C, Sikka S, Cheung B, et al. Towards major depressive disorder with and without prevention strategies: a systematic review. automated analysis of connectomes: the suicidal ideation. Ann Gen Psychiatry. JAMA. 2005;294(16):2064–2074.PubMedCrossRef configurable pipeline for the analysis of 2018;17(1):37.PubMed CrossRef Mundt JC, Greist JH, Jefferson JW, et al. connectomes (c-pac). Front Neuroinform. Li J, Duan X, Cui Q, et al. More than just statics: Prediction of suicidal behavior in clinical 2013:42. temporal dynamics of intrinsic brain activity researchbylifetimesuicidalideationand 20. Avants BB, Tustison NJ, Song G, et al. A predicts the suicidal ideation in depressed behavior ascertained by the electronic reproducible evaluation of ANTs similarity patients. Psychol Med. 2019;49(5):852–860.PubMed CrossRef Columbia-Suicide Severity Rating Scale. J Clin metric performance in brain image Weng JC, Chou YS, Tsai YH, et al. Connectome Psychiatry. 2013;74(9):887–893.PubMed CrossRef registration. Neuroimage. analysis of brain functional network alterations 6. Zou Q, Wu CW, Stein EA, et al. Static and 2011;54(3):2033–2044.PubMed CrossRef in depressive patients with suicidal attempt. dynamic characteristics of cerebral blood flow Friston KJ, Williams S, Howard R, et al. J Clin Med.2019;8(11):1966.PubMedCrossRef during the resting state. Neuroimage. Movement-related effects in fMRI time-series. Chen VC, Chou YS, Tsai YH, et al. Resting-state 2009;48(3):515–524.PubMedCrossRef MagnResonMed.1996;35(3):346–355.PubMedCrossRef functionalconnectivityandbrainnetwork 7. Li Z, Zhu Y, Childress AR, et al. Relations R Core Team. R: A language and environment abnormalities in depressive patients with between BOLD fMRI-derived resting brain for statistical computing. Vienna, Austria: R suicidal ideation. Brain Topogr. activity and cerebral blood flow. PLoS One. Foundation for Statistical Computing; 2021. 2021;34(2):234–244.PubMed CrossRef 2012;7(9):e44556.PubMed CrossRef https://www.R-project.org/. 37. Ordaz SJ, Goyer MS, Ho TC, et al. Network basis Publisher Copyright: © 2022 Physicians Postgraduate Press Inc.. All rights reserved.

PY - 2022/5

Y1 - 2022/5

UR - http://www.scopus.com/inward/record.url?scp=85135942225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85135942225&partnerID=8YFLogxK

U2 - 10.4088/JCP.21m14054

DO - 10.4088/JCP.21m14054

M3 - Article

AN - SCOPUS:85135942225

SN - 0160-6689

VL - 83

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

IS - 3

M1 - 21m14054

ER -