Jadomycins inhibit type II topoisomerases and promote DNA damage and apoptosis in multidrug-resistant triple-negative breast cancer cells

TY - JOUR

T1 - Jadomycins inhibit type II topoisomerases and promote DNA damage and apoptosis in multidrug-resistant triple-negative breast cancer cells

AU - Hall, Steven R.

AU - Toulany, Jay

AU - Bennett, Leah G.

AU - Martinez-Farina, Camilo F.

AU - Robertson, Andrew W.

AU - Jakeman, David L.

AU - Goralski, Kerry B.

N1 - Funding Information: K.B.G. received research infrastructure funding from the Canadian Foundation for Innovation Leaders Opportunity Fund. The research was supported by operating grants from the Canadian Breast Cancer Foundation— Atlantic Chapter, the Dalhousie Pharmacy Endowment, the Beatrice Hunter Cancer Research Institute, and the Dalhousie University Faculty of Health Professions to K.B.G.; and from the Nova Scotia Health Research Foundation, the Natural Sciences and Engineering Research Council, and the Canadian Institutes of Health Research to D.L.J. S.R.H. was supported by a Nova Scotia Health Research Foundation Scotia Scholar Award and a Level 2 Izaak Walton Killam Predoctoral Scholarship. Publisher Copyright: Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

PY - 2017/11

Y1 - 2017/11

UR - http://www.scopus.com/inward/record.url?scp=85031023870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031023870&partnerID=8YFLogxK

U2 - 10.1124/jpet.117.241125

DO - 10.1124/jpet.117.241125

M3 - Article

C2 - 28904004

AN - SCOPUS:85031023870

SN - 0022-3565

VL - 363

SP - 196

EP - 210

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

IS - 2

ER -