Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors

TY - JOUR

T1 - Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors

AU - Potter, Elizabeth

AU - Jha, Mamta

AU - Bhullar, Khushwant S.

AU - Rupasinghe, H. P.Vasantha

AU - Balzarini, Jan

AU - Jha, Amitabh

N1 - Funding Information: The authors thank the following agencies for financial support, namely the Nova Scotia Health Research Foundation (A.J., E.P.), Natural Sciences and Engineering Research Council (NSERC) of Canada (A.J.), Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (J.B.). Appreciation is extended to Mrs. Lizette van Berckelaer for conducting the HeLa, CEM and L1210 assays. H.P.V.R. gratefully acknowledges funding from the Canada Research Chair program and the Discovery Grant program of the Natural Sciences and Engineering Research Council (NSERC) of Canada. Publisher Copyright: © 2014 Elsevier Ltd. All rights reserved.

PY - 2015/2/1

Y1 - 2015/2/1

UR - http://www.scopus.com/inward/record.url?scp=84921423338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921423338&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2014.12.042

DO - 10.1016/j.bmc.2014.12.042

M3 - Article

C2 - 25577711

AN - SCOPUS:84921423338

SN - 0968-0896

VL - 23

SP - 411

EP - 421

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 3

ER -