@article{f845ac0c1cf54ee9bccd1e6cacc6f199,
title = "Intracarotid amobarbital memory protocol: Muteness, dysphasia, and variations in arterial distribution of the drug do not affect recognition results",
author = "Smith, {Isabel M.} and Jeannette McGlone and Fox, {Allan J.}",
note = "Funding Information: worthwhile or that it should be replaced by a riskier one. We agree with Miller and Fedio (5) that to advocate replacement of the ICA with the PCA technique is inappropriate, given that the two procedures are designed to address different problems. As yet, there has been no demonstration of the validity of the PCA protocol in predicting global amnesia. We see no need to abandon the ICA memory protocol in order to pursue other techniques that address more specific questions, such as the prediction of verbal memory loss. Furthermore, for those centers that retain the traditional (i.e., mesial and lateral) surgical approach to temporal lobectomy, the ICA protocol better mimics the effects of surgery. Given these assumptions, what are the practical implications of the present findings for interpretation of the results of ICA amobarbital memory testing? One suggestion might be that, when memory failure occurs following ipsilateral dominant injection, a repeat injection using a lower dose of the drug (24) might be warranted. The rationale here is that some memory failures under high amobarbital dosages might reflect drug effects that are not memory-specific. Alternatively, as suggested by Miller and Fedio (5), the appropriate use of the PCA amobarbital test might be for those patients for whom risk of postoperative amnesia is high, and the interpretation of ICA memory test results can be made less confidently. Recognition failure following ipsilateral dominant-hemisphere injection would constitute such a circumstance. Acknowledgment: The authors gratefully acknowledge the clinical contributions of Drs. John Girvin, Warren Blume, Richard McLachlan, Howard Reich-man, John Kaufman, and Sylvia Garcia. The psychometric assessments and computer assistance provided by Lucy Carriere, Janice Howell, Lorraine McFadden, and Chantal Bertrand are appreciated as are Dr. Susan Pigott's comments on the manuscript. The research was supported by The University Hospital Foundation and the Medical Research Council of Canada, and by an MRC Studentship to Isabel M. Smith.",
year = "1993",
doi = "10.1016/S0896-6974(05)80092-1",
language = "English",
volume = "6",
pages = "75--84",
journal = "Journal of Epilepsy",
issn = "0896-6974",
number = "2",
}