Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors

Keyphrases

• Cytotoxicity 100%
• Aryl 100%
• 4-Piperidones 100%
• Curcumin 100%
• Ortho 100%
• Topoisomerase IIα 100%
• Novel Groups 100%
• Alpha Inhibitors 100%
• In Vitro Toxicity 50%
• Mode of Action 50%
• Potent Antioxidant 50%
• T Cells 50%
• Toxicity Analysis 50%
• Human Fibroblasts 50%
• Diamide 50%
• Radical Production 50%
• Simplified Analog 50%
• Molecular Modeling Studies 50%
• Antioxidant in Vitro 50%
• Peroxyl Radicals 50%
• MOLT-4 50%
• Leukemic Cells 50%
• L1210 50%
• Maleic 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Cytotoxicity 100%
• DNA Topoisomerase (ATP Hydrolysing) 100%
• Curcumin 100%
• Piperidone Derivative 100%
• Antioxidant 50%
• Diamide 50%
• Murine 50%
• Peroxy Radical 50%