Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice

John Mach, Gizem Gemikonakli, Caitlin Logan, Brent Vander Wyk, Heather Allore, Swathi Ekambareshwar, Alice E. Kane, Susan E. Howlett, Rafael de Cabo, David G. Le Couteur, Sarah N. Hilmer