Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor

Francesca Gado; Kawthar A. Mohamed; Serena Meini; Rebecca Ferrisi; Simone Bertini; Maria Digiacomo; Felicia D'Andrea; Lesley A. Stevenson; Robert B. Laprairie; Roger G. Pertwee; Clementina Manera

doi:10.1016/j.ejmech.2020.113116

Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor

Francesca Gado, Kawthar A. Mohamed, Serena Meini, Rebecca Ferrisi, Simone Bertini, Maria Digiacomo, Felicia D'Andrea, Lesley A. Stevenson, Robert B. Laprairie, Roger G. Pertwee, Clementina Manera

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Original language	English
Article number	113116
Journal	European Journal of Medicinal Chemistry
Volume	211
DOIs	https://doi.org/10.1016/j.ejmech.2020.113116
Publication status	Published - Feb 5 2021
Externally published	Yes

ASJC Scopus Subject Areas

Drug Discovery
Pharmacology
Organic Chemistry

Keywords

2-Oxopyridine-3-carboxamide
CB2 cannabinoid receptor
Positive allosteric modulator
Structure-activity relationships

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10.1016/j.ejmech.2020.113116

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Gado, F., Mohamed, K. A., Meini, S., Ferrisi, R., Bertini, S., Digiacomo, M., D'Andrea, F., Stevenson, L. A., Laprairie, R. B., Pertwee, R. G., & Manera, C. (2021). Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor. European Journal of Medicinal Chemistry, 211, Article 113116. https://doi.org/10.1016/j.ejmech.2020.113116

Gado, F, Mohamed, KA, Meini, S, Ferrisi, R, Bertini, S, Digiacomo, M, D'Andrea, F, Stevenson, LA, Laprairie, RB, Pertwee, RG & Manera, C 2021, 'Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor', European Journal of Medicinal Chemistry, vol. 211, 113116. https://doi.org/10.1016/j.ejmech.2020.113116

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AU - Gado, Francesca

AU - Mohamed, Kawthar A.

AU - Meini, Serena

AU - Ferrisi, Rebecca

AU - Bertini, Simone

AU - Digiacomo, Maria

AU - D'Andrea, Felicia

AU - Stevenson, Lesley A.

AU - Laprairie, Robert B.

AU - Pertwee, Roger G.

AU - Manera, Clementina

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KW - Positive allosteric modulator

KW - Structure-activity relationships

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Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor

ASJC Scopus Subject Areas

Keywords

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