@article{a23225ec2c9b453fa847b15d1d8a0f90,
title = "Upfront Combination Therapy, Compared With Monotherapy, for Patients Not Previously Treated With a Biologic Agent Associates With Reduced Risk of Inflammatory Bowel Disease-related Complications in a Population-based Cohort Study",
author = "Targownik, {Laura E.} and Benchimol, {Eric I.} and Bernstein, {Charles N.} and Harminder Singh and Lisa Lix and A. Tennakoon and Stella Leung and Antonio Avi{\~n}a and Stephanie Coward and Jennifer Jones and Gil Kaplan and Murthy, {Sanjay K.} and Nguyen, {Geoffrey C.} and Pe{\~n}a-S{\'a}nchez, {Juan Nicol{\'a}s}",
note = "Funding Information: Funding Supported through a grant from the Crohn's and Colitis Canada Grants in Aid of Research and the Helmsley Foundation. Conflicts of interest These authors disclose the following: Laura Targownik has received investigator initiated funding from Janssen Canada and served on advisory boards for AbbVie Canada, Takeda Canada, Merck Canada, Pfizer Canada, and Mallinckrodt USA. Charles Bernstein has served on advisory Boards for AbbVie Canada, Ferring Canada, Janssen Canada, Shire Canada, Takeda Canada, and Pfizer Canada; has been a Consultant for Mylan Pharmaceuticals; has received educational grants from AbbVie Canada, Shire Canada, Takeda Canada, and Janssen Canada; has been on Speaker's panel for AbbVie Canada, Ferring Canada, and Shire Canada; and has received research funding from AbbVie Canada. Harminder Singh has been on advisory board of Pendopharm, Ferring, and Merck Canada and has received research funding from Merck Canada. Jennifer Jones has been on advisory boards, acted as a consultant, and has been a speaker for Advisory, and received consultant, speaker fees for Janssen and AbbVie. Gil Kaplan has received speaking or consultancy honoraria from AbbVie, Janssen, Pfizer, and Shire and has received a grant from AbbVie, Janssen, Merck, and Shire. Sanjay Murthy has served on advisory boards for AbbVie, Ferring, Shire, Takeda, and Pfizer. The remaining authors disclose no conflicts. Funding Supported through a grant from the Crohn's and Colitis Canada Grants in Aid of Research and the Helmsley Foundation. The authors thank the Canadian Gastrointestinal Epidemiologic Consortium for their technical support. Conflicts of interest These authors disclose the following: Laura Targownik has received investigator initiated funding from Janssen Canada and served on advisory boards for AbbVie Canada, Takeda Canada, Merck Canada, Pfizer Canada, and Mallinckrodt USA. Charles Bernstein has served on advisory Boards for AbbVie Canada, Ferring Canada, Janssen Canada, Shire Canada, Takeda Canada, and Pfizer Canada; has been a Consultant for Mylan Pharmaceuticals; has received educational grants from AbbVie Canada, Shire Canada, Takeda Canada, and Janssen Canada; has been on Speaker's panel for AbbVie Canada, Ferring Canada, and Shire Canada; and has received research funding from AbbVie Canada. Harminder Singh has been on advisory board of Pendopharm, Ferring, and Merck Canada and has received research funding from Merck Canada. Jennifer Jones has been on advisory boards, acted as a consultant, and has been a speaker for Advisory, and received consultant, speaker fees for Janssen and AbbVie. Gil Kaplan has received speaking or consultancy honoraria from AbbVie, Janssen, Pfizer, and Shire and has received a grant from AbbVie, Janssen, Merck, and Shire. Sanjay Murthy has served on advisory boards for AbbVie, Ferring, Shire, Takeda, and Pfizer. The remaining authors disclose no conflicts. Funding Supported through a grant from the Crohn's and Colitis Canada Grants in Aid of Research and the Helmsley Foundation. Funding Information: Funding Supported through a grant from the Crohn's and Colitis Canada Grants in Aid of Research and the Helmsley Foundation. Publisher Copyright: {\textcopyright} 2019 AGA Institute",
year = "2019",
month = aug,
doi = "10.1016/j.cgh.2018.11.003",
language = "English",
volume = "17",
pages = "1788--1798.e2",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "9",
}