Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Eric S. Pringle; Brett A. Duguay; Maxwell P. Bui-Marinos; Rory P. Mulloy; Shelby L. Landreth; Krishna Swaroop Desireddy; Stacia M. Dolliver; Shan Ying; Taylor Caddell; Trinity H. Tooley; Patrick D. Slaine; Stephen L. Bearne; Darryl Falzarano; Jennifer A. Corcoran; Denys A. Khaperskyy; Craig McCormick

doi:10.1371/journal.ppat.1010832

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Eric S. Pringle, Brett A. Duguay, Maxwell P. Bui-Marinos, Rory P. Mulloy, Shelby L. Landreth, Krishna Swaroop Desireddy, Stacia M. Dolliver, Shan Ying, Taylor Caddell, Trinity H. Tooley, Patrick D. Slaine, Stephen L. Bearne, Darryl Falzarano, Jennifer A. Corcoran, Denys A. Khaperskyy, Craig McCormick

Decision Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Original language	English
Article number	e1010832
Journal	PLoS Pathogens
Volume	18
Issue number	9
DOIs	https://doi.org/10.1371/journal.ppat.1010832
Publication status	Published - Sept 2022

ASJC Scopus Subject Areas

Parasitology
Microbiology
Immunology
Molecular Biology
Genetics
Virology

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10.1371/journal.ppat.1010832

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Pringle, E. S., Duguay, B. A., Bui-Marinos, M. P., Mulloy, R. P., Landreth, S. L., Desireddy, K. S., Dolliver, S. M., Ying, S., Caddell, T., Tooley, T. H., Slaine, P. D., Bearne, S. L., Falzarano, D., Corcoran, J. A., Khaperskyy, D. A., & McCormick, C. (2022). Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. PLoS Pathogens, 18(9), Article e1010832. https://doi.org/10.1371/journal.ppat.1010832

Pringle, ES, Duguay, BA, Bui-Marinos, MP, Mulloy, RP, Landreth, SL, Desireddy, KS, Dolliver, SM, Ying, S, Caddell, T, Tooley, TH, Slaine, PD, Bearne, SL, Falzarano, D, Corcoran, JA, Khaperskyy, DA & McCormick, C 2022, 'Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions', PLoS Pathogens, vol. 18, no. 9, e1010832. https://doi.org/10.1371/journal.ppat.1010832

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Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

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Researchers discover existing drug can disrupt coronavirus replication

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Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

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Researchers discover existing drug can disrupt coronavirus replication

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