Abstract
Aldehydes and ketones are present in wide range of compounds including drugs, food and environmental pollutants. To study their effects on biological systems, a range of appropriate cell-based assays can be used, which investigate the nature of damage caused. The role of aldo-keto reductases in protecting against these toxic effects has been assessed in a variety of experimental systems, including cell lines that naturally express high levels of aldo-keto reductase enzymes, and constructed cell lines that express individual components of a particular detoxication pathway.
| Original language | English |
|---|---|
| Title of host publication | ALDO-KETO REDUCTASES AND TOXICANT METABOLISM |
| Editors | TM Penning, JM Petrash |
| Place of Publication | WASHINGTON |
| Publisher | American Chemical Society |
| Pages | 183-196 |
| Number of pages | 14 |
| ISBN (Print) | 0-8412-3846-4 |
| Publication status | Published - 2004 |
| Event | Symposium on Aldo-Keto Reductases and Toxicant Metabolism held at the 224th National Meeting of the American-Chemical-Society - Boston, United States Duration: Aug 20 2002 → … |
Conference
| Conference | Symposium on Aldo-Keto Reductases and Toxicant Metabolism held at the 224th National Meeting of the American-Chemical-Society |
|---|---|
| Country/Territory | United States |
| City | Boston |
| Period | 8/20/02 → … |