The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

Mengnan Xu; Shekoufeh Almasi; Yiming Yang; Chi Yan; Andra Mihaela Sterea; Alia Kazim Rizvi Syeda; Bing Shen; Clements Richard Derek; Peng Huang; Shashi Gujar; Jun Wang; Wei Xing Zong; Mohamed Trebak; Yassine El Hiani; Xian Ping Dong

doi:10.1016/j.ceca.2019.02.010

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

Mengnan Xu, Shekoufeh Almasi, Yiming Yang, Chi Yan, Andra Mihaela Sterea, Alia Kazim Rizvi Syeda, Bing Shen, Clements Richard Derek, Peng Huang, Shashi Gujar, Jun Wang, Wei Xing Zong, Mohamed Trebak, Yassine El Hiani, Xian Ping Dong

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Original language	English
Pages (from-to)	80-88
Number of pages	9
Journal	Cell Calcium
Volume	79
DOIs	https://doi.org/10.1016/j.ceca.2019.02.010
Publication status	Published - May 2019
Externally published	Yes

ASJC Scopus Subject Areas

Physiology
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ceca.2019.02.010

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Xu, M., Almasi, S., Yang, Y., Yan, C., Sterea, A. M., Rizvi Syeda, A. K., Shen, B., Richard Derek, C., Huang, P., Gujar, S., Wang, J., Zong, W. X., Trebak, M., El Hiani, Y., & Dong, X. P. (2019). The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. Cell Calcium, 79, 80-88. https://doi.org/10.1016/j.ceca.2019.02.010

Xu, M, Almasi, S, Yang, Y, Yan, C, Sterea, AM, Rizvi Syeda, AK, Shen, B, Richard Derek, C, Huang, P, Gujar, S, Wang, J, Zong, WX, Trebak, M, El Hiani, Y & Dong, XP 2019, 'The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways', Cell Calcium, vol. 79, pp. 80-88. https://doi.org/10.1016/j.ceca.2019.02.010

@article{3a70d1d183b24a2cb644e016ef9e5b0e,

title = "The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways",

author = "Mengnan Xu and Shekoufeh Almasi and Yiming Yang and Chi Yan and Sterea, {Andra Mihaela} and {Rizvi Syeda}, {Alia Kazim} and Bing Shen and {Richard Derek}, Clements and Peng Huang and Shashi Gujar and Jun Wang and Zong, {Wei Xing} and Mohamed Trebak and {El Hiani}, Yassine and Dong, {Xian Ping}",

note = "Funding Information: This work was supported by DMRF Equipment Grant , CIHR grant ( PJT-156102 ), and CFI Leaders Opportunity Fund -Funding for research infrastructure ( 29291 ). We thank Mitsunori Fukuda for the Syt-VII-DN plasmid and Haoxing Xu for his constant support. We appreciate the encouragement and helpful comments from other members of the Dong laboratory and El Hiani laboratories. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = may,

doi = "10.1016/j.ceca.2019.02.010",

language = "English",

volume = "79",

pages = "80--88",

journal = "Cell Calcium",

issn = "0143-4160",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

AU - Xu, Mengnan

AU - Almasi, Shekoufeh

AU - Yang, Yiming

AU - Yan, Chi

AU - Sterea, Andra Mihaela

AU - Rizvi Syeda, Alia Kazim

AU - Shen, Bing

AU - Richard Derek, Clements

AU - Huang, Peng

AU - Gujar, Shashi

AU - Wang, Jun

AU - Zong, Wei Xing

AU - Trebak, Mohamed

AU - El Hiani, Yassine

AU - Dong, Xian Ping

N1 - Funding Information: This work was supported by DMRF Equipment Grant , CIHR grant ( PJT-156102 ), and CFI Leaders Opportunity Fund -Funding for research infrastructure ( 29291 ). We thank Mitsunori Fukuda for the Syt-VII-DN plasmid and Haoxing Xu for his constant support. We appreciate the encouragement and helpful comments from other members of the Dong laboratory and El Hiani laboratories. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/5

Y1 - 2019/5

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UR - http://www.scopus.com/inward/citedby.url?scp=85063011838&partnerID=8YFLogxK

U2 - 10.1016/j.ceca.2019.02.010

DO - 10.1016/j.ceca.2019.02.010

M3 - Article

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AN - SCOPUS:85063011838

SN - 0143-4160

VL - 79

SP - 80

EP - 88

JO - Cell Calcium

JF - Cell Calcium

ER -

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

ASJC Scopus Subject Areas

UN SDGs

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