Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center

Amar Nath Sharma; Lia Grandinetti; Erin R. Johnson; Martin St Maurice; Stephen L. Bearne

doi:10.1021/acs.biochem.0c00478

Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center

Amar Nath Sharma, Lia Grandinetti, Erin R. Johnson, Martin St Maurice, Stephen L. Bearne

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3026-3037
Number of pages	12
Journal	Biochemistry
Volume	59
Issue number	33
DOIs	https://doi.org/10.1021/acs.biochem.0c00478
Publication status	Published - Aug 25 2020

ASJC Scopus Subject Areas

Biochemistry

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10.1021/acs.biochem.0c00478

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title = "Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center",

author = "Sharma, {Amar Nath} and Lia Grandinetti and Johnson, {Erin R.} and {St Maurice}, Martin and Bearne, {Stephen L.}",

note = "Funding Information: This work was supported by Discovery Grants from the Natural Sciences and Engineering Research Council (NSERC) of Canada to S.L.B. (Grant RGPIN-2016-05083) and E.R.J. (Grant RGPIN-2016-05795). Funding Information: The authors thank Dr. Mike Lumsden (NMR-3) for assistance with the NMR experiments and Oliver Kuehm for assistance with analysis of the ITC data. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. Use of LS-CAT Sector 21 was supported by the Michigan Economic Development Corp. and the Michigan Technology Tri-Corridor (Grant 085P1000817). Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society.",

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doi = "10.1021/acs.biochem.0c00478",

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T2 - Boron as a Mimic of a Carbon Acid Center

AU - Sharma, Amar Nath

AU - Grandinetti, Lia

AU - Johnson, Erin R.

AU - St Maurice, Martin

AU - Bearne, Stephen L.

N1 - Funding Information: This work was supported by Discovery Grants from the Natural Sciences and Engineering Research Council (NSERC) of Canada to S.L.B. (Grant RGPIN-2016-05083) and E.R.J. (Grant RGPIN-2016-05795). Funding Information: The authors thank Dr. Mike Lumsden (NMR-3) for assistance with the NMR experiments and Oliver Kuehm for assistance with analysis of the ITC data. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. Use of LS-CAT Sector 21 was supported by the Michigan Economic Development Corp. and the Michigan Technology Tri-Corridor (Grant 085P1000817). Publisher Copyright: Copyright © 2020 American Chemical Society.

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Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center

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