Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

Brendan T. McKeown; Nicholas J. Relja; Steven R. Hall; Simon Gebremeskel; Jeanna M. Macleod; Chansey J. Veinotte; Leah G. Bennett; Leanne B. Ohlund; Lekha Sleno; David L. Jakeman; Jason N. Berman; Brent Johnston; Kerry B. Goralski

doi:10.1139/cjpp-2022-0152

Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

Brendan T. McKeown, Nicholas J. Relja, Steven R. Hall, Simon Gebremeskel, Jeanna M. Macleod, Chansey J. Veinotte, Leah G. Bennett, Leanne B. Ohlund, Lekha Sleno, David L. Jakeman, Jason N. Berman, Brent Johnston, Kerry B. Goralski

Economics, Econometrics and Finance

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Original language	English
Pages (from-to)	1065-1076
Number of pages	12
Journal	Canadian Journal of Physiology and Pharmacology
Volume	100
Issue number	11
DOIs	https://doi.org/10.1139/cjpp-2022-0152
Publication status	Published - 2022

ASJC Scopus Subject Areas

Physiology (medical)
Physiology
Pharmacology

Keywords

breast cancer
jadomycin B
mouse
pharmacokinetics
toxicity
zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1139/cjpp-2022-0152

Cite this

McKeown, B. T., Relja, N. J., Hall, S. R., Gebremeskel, S., Macleod, J. M., Veinotte, C. J., Bennett, L. G., Ohlund, L. B., Sleno, L., Jakeman, D. L., Berman, J. N., Johnston, B., & Goralski, K. B. (2022). Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models. Canadian Journal of Physiology and Pharmacology, 100(11), 1065-1076. https://doi.org/10.1139/cjpp-2022-0152

McKeown, BT, Relja, NJ, Hall, SR, Gebremeskel, S, Macleod, JM, Veinotte, CJ, Bennett, LG, Ohlund, LB, Sleno, L, Jakeman, DL, Berman, JN, Johnston, B & Goralski, KB 2022, 'Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models', Canadian Journal of Physiology and Pharmacology, vol. 100, no. 11, pp. 1065-1076. https://doi.org/10.1139/cjpp-2022-0152

@article{a84aeeb2912246279449cd9e6f1f0d24,

title = "Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models",

keywords = "breast cancer, jadomycin B, mouse, pharmacokinetics, toxicity, zebrafish",

author = "McKeown, {Brendan T.} and Relja, {Nicholas J.} and Hall, {Steven R.} and Simon Gebremeskel and Macleod, {Jeanna M.} and Veinotte, {Chansey J.} and Bennett, {Leah G.} and Ohlund, {Leanne B.} and Lekha Sleno and Jakeman, {David L.} and Berman, {Jason N.} and Brent Johnston and Goralski, {Kerry B.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s).",

year = "2022",

doi = "10.1139/cjpp-2022-0152",

language = "English",

volume = "100",

pages = "1065--1076",

journal = "Canadian Journal of Physiology and Pharmacology",

issn = "0008-4212",

publisher = "National Research Council of Canada",

number = "11",

}

TY - JOUR

T1 - Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

AU - McKeown, Brendan T.

AU - Relja, Nicholas J.

AU - Hall, Steven R.

AU - Gebremeskel, Simon

AU - Macleod, Jeanna M.

AU - Veinotte, Chansey J.

AU - Bennett, Leah G.

AU - Ohlund, Leanne B.

AU - Sleno, Lekha

AU - Jakeman, David L.

AU - Berman, Jason N.

AU - Johnston, Brent

AU - Goralski, Kerry B.

PY - 2022

Y1 - 2022

KW - breast cancer

KW - jadomycin B

KW - mouse

KW - pharmacokinetics

KW - toxicity

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85141170080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141170080&partnerID=8YFLogxK

U2 - 10.1139/cjpp-2022-0152

DO - 10.1139/cjpp-2022-0152

M3 - Article

C2 - 35985040

AN - SCOPUS:85141170080

SN - 0008-4212

VL - 100

SP - 1065

EP - 1076

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

IS - 11

ER -

Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this