MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

Thomas Harman; Michael Udoh; Dan L. McElroy; Lyndsey L. Anderson; Richard C. Kevin; Samuel D. Banister; Adam Ametovski; Jack Markham; Chris Bladen; Peter T. Doohan; Quentin Greba; Robert B. Laprairie; Terrance P. Snutch; Iain S. McGregor; John G. Howland; Jonathon C. Arnold

doi:10.3389/fphys.2023.1086243

MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

Thomas Harman, Michael Udoh, Dan L. McElroy, Lyndsey L. Anderson, Richard C. Kevin, Samuel D. Banister, Adam Ametovski, Jack Markham, Chris Bladen, Peter T. Doohan, Quentin Greba, Robert B. Laprairie, Terrance P. Snutch, Iain S. McGregor, John G. Howland, Jonathon C. Arnold

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Original language	English
Article number	1086243
Journal	Frontiers in Physiology
Volume	14
DOIs	https://doi.org/10.3389/fphys.2023.1086243
Publication status	Published - 2023
Externally published	Yes

ASJC Scopus Subject Areas

Physiology (medical)
Physiology

Keywords

6 Hz
Ca3 channels
Dravet syndrome
GAERS
cannabinoid
epilepsy
mepirapim

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10.3389/fphys.2023.1086243

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Harman, T., Udoh, M., McElroy, D. L., Anderson, L. L., Kevin, R. C., Banister, S. D., Ametovski, A., Markham, J., Bladen, C., Doohan, P. T., Greba, Q., Laprairie, R. B., Snutch, T. P., McGregor, I. S., Howland, J. G., & Arnold, J. C. (2023). MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy. Frontiers in Physiology, 14, Article 1086243. https://doi.org/10.3389/fphys.2023.1086243

Harman, T, Udoh, M, McElroy, DL, Anderson, LL, Kevin, RC, Banister, SD, Ametovski, A, Markham, J, Bladen, C, Doohan, PT, Greba, Q, Laprairie, RB, Snutch, TP, McGregor, IS, Howland, JG & Arnold, JC 2023, 'MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy', Frontiers in Physiology, vol. 14, 1086243. https://doi.org/10.3389/fphys.2023.1086243

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title = "MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy",

keywords = "6 Hz, Ca3 channels, Dravet syndrome, GAERS, cannabinoid, epilepsy, mepirapim",

author = "Thomas Harman and Michael Udoh and McElroy, {Dan L.} and Anderson, {Lyndsey L.} and Kevin, {Richard C.} and Banister, {Samuel D.} and Adam Ametovski and Jack Markham and Chris Bladen and Doohan, {Peter T.} and Quentin Greba and Laprairie, {Robert B.} and Snutch, {Terrance P.} and McGregor, {Iain S.} and Howland, {John G.} and Arnold, {Jonathon C.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Harman, Udoh, McElroy, Anderson, Kevin, Banister, Ametovski, Markham, Bladen, Doohan, Greba, Laprairie, Snutch, McGregor, Howland and Arnold.",

year = "2023",

doi = "10.3389/fphys.2023.1086243",

language = "English",

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journal = "Frontiers in Physiology",

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T1 - MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

AU - Harman, Thomas

AU - Udoh, Michael

AU - McElroy, Dan L.

AU - Anderson, Lyndsey L.

AU - Kevin, Richard C.

AU - Banister, Samuel D.

AU - Ametovski, Adam

AU - Markham, Jack

AU - Bladen, Chris

AU - Doohan, Peter T.

AU - Greba, Quentin

AU - Laprairie, Robert B.

AU - Snutch, Terrance P.

AU - McGregor, Iain S.

AU - Howland, John G.

AU - Arnold, Jonathon C.

PY - 2023

Y1 - 2023

KW - 6 Hz

KW - Ca3 channels

KW - Dravet syndrome

KW - GAERS

KW - cannabinoid

KW - epilepsy

KW - mepirapim

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DO - 10.3389/fphys.2023.1086243

M3 - Article

AN - SCOPUS:85153519064

SN - 1664-042X

VL - 14

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 1086243

ER -

MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy

ASJC Scopus Subject Areas

Keywords

Access to Document

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