Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes

Purvi C. Trivedi; Jordan J. Bartlett; Lester J. Perez; Keith R. Brunt; Jean Francois Legare; Ansar Hassan; Petra C. Kienesberger; Thomas Pulinilkunnil

doi:10.1016/j.bbalip.2016.09.004

Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes

Purvi C. Trivedi, Jordan J. Bartlett, Lester J. Perez, Keith R. Brunt, Jean Francois Legare, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Original language	English
Pages (from-to)	1893-1910
Number of pages	18
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1861
Issue number	12
DOIs	https://doi.org/10.1016/j.bbalip.2016.09.004
Publication status	Published - Dec 1 2016
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

Keywords

Cardiomyopathy
Glucolipotoxicity
LAMP-2A
Lysosomal autophagy
Obesity and diabetes
TFEB

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbalip.2016.09.004

Cite this

Trivedi, P. C., Bartlett, J. J., Perez, L. J., Brunt, K. R., Legare, J. F., Hassan, A., Kienesberger, P. C., & Pulinilkunnil, T. (2016). Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861(12), 1893-1910. https://doi.org/10.1016/j.bbalip.2016.09.004

Trivedi, PC, Bartlett, JJ, Perez, LJ, Brunt, KR , Legare, JF , Hassan, A , Kienesberger, PC & Pulinilkunnil, T 2016, 'Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, no. 12, pp. 1893-1910. https://doi.org/10.1016/j.bbalip.2016.09.004

@article{2011c197bc2545d5ab9d88d2f306a6b8,

title = "Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes",

keywords = "Cardiomyopathy, Glucolipotoxicity, LAMP-2A, Lysosomal autophagy, Obesity and diabetes, TFEB",

author = "Trivedi, {Purvi C.} and Bartlett, {Jordan J.} and Perez, {Lester J.} and Brunt, {Keith R.} and Legare, {Jean Francois} and Ansar Hassan and Kienesberger, {Petra C.} and Thomas Pulinilkunnil",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.bbalip.2016.09.004",

language = "English",

volume = "1861",

pages = "1893--1910",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

issn = "1388-1981",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes

AU - Trivedi, Purvi C.

AU - Bartlett, Jordan J.

AU - Perez, Lester J.

AU - Brunt, Keith R.

AU - Legare, Jean Francois

AU - Hassan, Ansar

AU - Kienesberger, Petra C.

AU - Pulinilkunnil, Thomas

PY - 2016/12/1

Y1 - 2016/12/1

KW - Cardiomyopathy

KW - Glucolipotoxicity

KW - LAMP-2A

KW - Lysosomal autophagy

KW - Obesity and diabetes

KW - TFEB

UR - http://www.scopus.com/inward/record.url?scp=84988661115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988661115&partnerID=8YFLogxK

U2 - 10.1016/j.bbalip.2016.09.004

DO - 10.1016/j.bbalip.2016.09.004

M3 - Article

C2 - 27620487

AN - SCOPUS:84988661115

SN - 1388-1981

VL - 1861

SP - 1893

EP - 1910

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 12

ER -

Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this