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Evolutionary trace analysis of the Kunitz/BPTI family of proteins: Functional divergence may have been based on conformational adjustment
Leighton Pritchard,
Mark J. Dufton
Research output
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Contribution to journal
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Article
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peer-review
59
Citations (Scopus)
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Dive into the research topics of 'Evolutionary trace analysis of the Kunitz/BPTI family of proteins: Functional divergence may have been based on conformational adjustment'. Together they form a unique fingerprint.
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Keyphrases
Antiproteinase
50%
Binding Selectivity
25%
Bovine Pancreatic Trypsin Inhibitor
100%
Chain Segment
25%
Class-specific
75%
Evolutionary Selection
25%
Evolutionary Trace
100%
Functional Class
50%
Functional Divergence
100%
Functional Diversification
25%
Functional Evolution
25%
Intermolecular Recognition
25%
Kunitz
100%
Molecular Stability
25%
Novel Peptide
25%
Peptide Binding Site
25%
Potassium Channel Blockers
25%
Primary Sequence
25%
Retargeting
25%
Serine Protease Inhibitor
25%
Serine Proteinase
25%
Side Chain
100%
Site Substitution
25%
Specific Positions
75%
Structural Evolution
25%
Target Recognition
25%
Tracing Method
25%
Biochemistry, Genetics and Molecular Biology
Aprotinin
100%
Binding Site
33%
Conformation
33%
Functional Divergence
100%
Molecular Stability
33%
Potassium Channel Blocker
33%
Serine Protease
66%