Disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate lyase enhances pathogen eradication by antibiotics

Keyphrases

• Antibiotics 100%
• Alginate Lyase 100%
• Tightly Bound Extracellular Polymeric Substances (TB-EPS) 100%
• Pathogen Removal 100%
• Polymeric Network 100%
• Pseudomonas Aeruginosa Biofilm 100%
• Biofilm 60%
• Lung 40%
• Cystic Fibrosis 40%
• Biofilm Infection 40%
• Treatment Failure 20%
• Combinational 20%
• Pseudomonas Aeruginosa (P. aeruginosa) 20%
• Bacterial Infection 20%
• Enzymatic Activity 20%
• P. Aeruginosa Infection 20%
• Biofilm Cells 20%
• Antibiotic Resistant 20%
• Alginate 20%
• Antibiofilm 20%
• 96-well Plate 20%
• Immunofluorescent Staining 20%
• Therapeutic Candidates 20%
• Synergy with Antibiotics 20%
• Pseudoalteromonas 20%
• Flow Cell 20%
• Biofilm Biomass 20%
• Therapeutic Action 20%
• Biofilm Disruption 20%
• Antibiotic Activity 20%
• Extracellular Polysaccharide 20%
• Thin Layer Chromatography 20%
• Mucoid Pseudomonas Aeruginosa 20%
• Clinical Relapse 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Antibiotic Agent 100%
• Pseudomonas aeruginosa 100%
• Alginic Acid 100%
• Pathogen Clearance 100%
• Lyase 100%
• Infection 42%
• Antibiotics 28%
• Cystic Fibrosis 28%
• Polysaccharide 14%
• Bacterial Infection 14%
• Pseudoalteromonas 14%

Immunology and Microbiology

• Pseudomonas aeruginosa 100%
• Biofilm 100%
• Polymerization 100%
• Pathogen Clearance 100%
• Bactericidal Activity 9%
• Antimicrobial Activity 9%
• Enzyme Activity 9%
• Pseudoalteromonas 9%
• Thin-Layer Chromatography 9%