Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure

Sumanta Garai; Peter C. Schaffer; Robert B. Laprairie; David R. Janero; Roger G. Pertwee; Alex Straiker; Ganesh A. Thakur

doi:10.1016/j.bmc.2021.116421

Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure

Sumanta Garai, Peter C. Schaffer, Robert B. Laprairie, David R. Janero, Roger G. Pertwee, Alex Straiker, Ganesh A. Thakur

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Original language	English
Article number	116421
Journal	Bioorganic and Medicinal Chemistry
Volume	50
DOIs	https://doi.org/10.1016/j.bmc.2021.116421
Publication status	Published - Nov 15 2021
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2021.116421

Cite this

Garai, S., Schaffer, P. C., Laprairie, R. B., Janero, D. R., Pertwee, R. G., Straiker, A., & Thakur, G. A. (2021). Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure. Bioorganic and Medicinal Chemistry, 50, Article 116421. https://doi.org/10.1016/j.bmc.2021.116421

Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure. / Garai, Sumanta; Schaffer, Peter C.; Laprairie, Robert B. et al.
In: Bioorganic and Medicinal Chemistry, Vol. 50, 116421, 15.11.2021.

Research output: Contribution to journal › Article › peer-review

Garai, S, Schaffer, PC, Laprairie, RB, Janero, DR, Pertwee, RG, Straiker, A & Thakur, GA 2021, 'Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure', Bioorganic and Medicinal Chemistry, vol. 50, 116421. https://doi.org/10.1016/j.bmc.2021.116421

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author = "Sumanta Garai and Schaffer, {Peter C.} and Laprairie, {Robert B.} and Janero, {David R.} and Pertwee, {Roger G.} and Alex Straiker and Thakur, {Ganesh A.}",

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AU - Straiker, Alex

AU - Thakur, Ganesh A.

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Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure

ASJC Scopus Subject Areas

UN SDGs

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