Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

Rebecca Ferrisi; Francesca Gado; Beatrice Polini; Caterina Ricardi; Kawthar A. Mohamed; Lesley A. Stevenson; Gabriella Ortore; Simona Rapposelli; Giuseppe Saccomanni; Roger G. Pertwee; Robert B. Laprairie; Clementina Manera; Grazia Chiellini

doi:10.3389/fchem.2022.984069

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB₂R)

Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Clementina Manera, Grazia Chiellini

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Original language	English
Article number	984069
Journal	Frontiers in Chemistry
Volume	10
DOIs	https://doi.org/10.3389/fchem.2022.984069
Publication status	Published - Sept 27 2022
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry

Keywords

CBR allosteric modulators
antiinflammatory activity
cannabinoid receptor type 2 (CBR)
dualsteric agents
human microglial cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fchem.2022.984069

Cite this

Ferrisi, R., Gado, F., Polini, B., Ricardi, C., Mohamed, K. A., Stevenson, L. A., Ortore, G., Rapposelli, S., Saccomanni, G., Pertwee, R. G., Laprairie, R. B., Manera, C., & Chiellini, G. (2022). Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB₂R). Frontiers in Chemistry, 10, Article 984069. https://doi.org/10.3389/fchem.2022.984069

Ferrisi, R, Gado, F, Polini, B, Ricardi, C, Mohamed, KA, Stevenson, LA, Ortore, G, Rapposelli, S, Saccomanni, G, Pertwee, RG, Laprairie, RB, Manera, C & Chiellini, G 2022, 'Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB₂R)', Frontiers in Chemistry, vol. 10, 984069. https://doi.org/10.3389/fchem.2022.984069

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AU - Ricardi, Caterina

AU - Mohamed, Kawthar A.

AU - Stevenson, Lesley A.

AU - Ortore, Gabriella

AU - Rapposelli, Simona

AU - Saccomanni, Giuseppe

AU - Pertwee, Roger G.

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