Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

Francesca Gado; Rebecca Ferrisi; Beatrice Polini; Kawthar A. Mohamed; Caterina Ricardi; Elena Lucarini; Sara Carpi; Federica Domenichini; Lesley A. Stevenson; Simona Rapposelli; Giuseppe Saccomanni; Paola Nieri; Gabriella Ortore; Roger G. Pertwee; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Grazia Chiellini; Robert B. Laprairie; Clementina Manera

doi:10.1021/acs.jmedchem.2c00582

Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

Francesca Gado, Rebecca Ferrisi, Beatrice Polini, Kawthar A. Mohamed, Caterina Ricardi, Elena Lucarini, Sara Carpi, Federica Domenichini, Lesley A. Stevenson, Simona Rapposelli, Giuseppe Saccomanni, Paola Nieri, Gabriella Ortore, Roger G. Pertwee, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Grazia Chiellini, Robert B. Laprairie, Clementina Manera

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Original language	English
Pages (from-to)	9918-9938
Number of pages	21
Journal	Journal of Medicinal Chemistry
Volume	65
Issue number	14
DOIs	https://doi.org/10.1021/acs.jmedchem.2c00582
Publication status	Published - Jul 28 2022
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

Access to Document

10.1021/acs.jmedchem.2c00582

Cite this

Gado, F., Ferrisi, R., Polini, B., Mohamed, K. A., Ricardi, C., Lucarini, E., Carpi, S., Domenichini, F., Stevenson, L. A., Rapposelli, S., Saccomanni, G., Nieri, P., Ortore, G., Pertwee, R. G., Ghelardini, C., Di Cesare Mannelli, L., Chiellini, G., Laprairie, R. B., & Manera, C. (2022). Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands. Journal of Medicinal Chemistry, 65(14), 9918-9938. https://doi.org/10.1021/acs.jmedchem.2c00582

Gado, F, Ferrisi, R, Polini, B, Mohamed, KA, Ricardi, C, Lucarini, E, Carpi, S, Domenichini, F, Stevenson, LA, Rapposelli, S, Saccomanni, G, Nieri, P, Ortore, G, Pertwee, RG, Ghelardini, C, Di Cesare Mannelli, L, Chiellini, G, Laprairie, RB & Manera, C 2022, 'Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands', Journal of Medicinal Chemistry, vol. 65, no. 14, pp. 9918-9938. https://doi.org/10.1021/acs.jmedchem.2c00582

@article{34e06e5b7777416ab3453cd04eb9315f,

title = "Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands",

author = "Francesca Gado and Rebecca Ferrisi and Beatrice Polini and Mohamed, {Kawthar A.} and Caterina Ricardi and Elena Lucarini and Sara Carpi and Federica Domenichini and Stevenson, {Lesley A.} and Simona Rapposelli and Giuseppe Saccomanni and Paola Nieri and Gabriella Ortore and Pertwee, {Roger G.} and Carla Ghelardini and {Di Cesare Mannelli}, Lorenzo and Grazia Chiellini and Laprairie, {Robert B.} and Clementina Manera",

year = "2022",

month = jul,

day = "28",

doi = "10.1021/acs.jmedchem.2c00582",

language = "English",

volume = "65",

pages = "9918--9938",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "14",

}

TY - JOUR

T1 - Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands

T2 - From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

AU - Gado, Francesca

AU - Ferrisi, Rebecca

AU - Polini, Beatrice

AU - Mohamed, Kawthar A.

AU - Ricardi, Caterina

AU - Lucarini, Elena

AU - Carpi, Sara

AU - Domenichini, Federica

AU - Stevenson, Lesley A.

AU - Rapposelli, Simona

AU - Saccomanni, Giuseppe

AU - Nieri, Paola

AU - Ortore, Gabriella

AU - Pertwee, Roger G.

AU - Ghelardini, Carla

AU - Di Cesare Mannelli, Lorenzo

AU - Chiellini, Grazia

AU - Laprairie, Robert B.

AU - Manera, Clementina

PY - 2022/7/28

Y1 - 2022/7/28

UR - http://www.scopus.com/inward/record.url?scp=85135373007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85135373007&partnerID=8YFLogxK

U2 - 10.1021/acs.jmedchem.2c00582

DO - 10.1021/acs.jmedchem.2c00582

M3 - Article

C2 - 35849804

AN - SCOPUS:85135373007

SN - 0022-2623

VL - 65

SP - 9918

EP - 9938

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 14

ER -

Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this