Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors

Amitabh Jha; Katherine M. Duffield; Matthew R. Ness; Sujatha Ravoori; Gabrielle Andrews; Khushwant S. Bhullar; H. P.Vasantha Rupasinghe; Jan Balzarini

doi:10.1016/j.bmc.2015.08.023

Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors

Amitabh Jha, Katherine M. Duffield, Matthew R. Ness, Sujatha Ravoori, Gabrielle Andrews, Khushwant S. Bhullar, H. P.Vasantha Rupasinghe, Jan Balzarini

Arts and Humanities

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Original language	English
Article number	12527
Pages (from-to)	6404-6417
Number of pages	14
Journal	Bioorganic and Medicinal Chemistry
Volume	23
Issue number	19
DOIs	https://doi.org/10.1016/j.bmc.2015.08.023
Publication status	Published - Oct 1 2015

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2015.08.023

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Jha, A., Duffield, K. M., Ness, M. R., Ravoori, S., Andrews, G., Bhullar, K. S., Rupasinghe, H. P. V., & Balzarini, J. (2015). Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic and Medicinal Chemistry, 23(19), 6404-6417. Article 12527. https://doi.org/10.1016/j.bmc.2015.08.023

Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. / Jha, Amitabh; Duffield, Katherine M.; Ness, Matthew R. et al.
In: Bioorganic and Medicinal Chemistry, Vol. 23, No. 19, 12527, 01.10.2015, p. 6404-6417.

Research output: Contribution to journal › Article › peer-review

Jha, A, Duffield, KM, Ness, MR, Ravoori, S, Andrews, G, Bhullar, KS, Rupasinghe, HPV & Balzarini, J 2015, 'Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors', Bioorganic and Medicinal Chemistry, vol. 23, no. 19, 12527, pp. 6404-6417. https://doi.org/10.1016/j.bmc.2015.08.023

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author = "Amitabh Jha and Duffield, {Katherine M.} and Ness, {Matthew R.} and Sujatha Ravoori and Gabrielle Andrews and Bhullar, {Khushwant S.} and Rupasinghe, {H. P.Vasantha} and Jan Balzarini",

note = "Funding Information: The following sources of financial support for this study are gratefully acknowledged: Nova Scotia Health Research Foundation (to A.J.) and Natural Sciences and Engineering Research Council of Canada (to A.J. and H.P.V.R.), the Canada Research Chair Program (to H.P.V.R.), Belgian Fonds voor Geneeskundig Wetenschappelik Onderzoek (to J.B.), Pfizer Summer Undergraduate Research Fellowship (to K.D. and M.N.). Appreciation is extended to Mrs. Lizette van Berckelaer for conducting the Molt 4/C8, CEM and L1210 assays, the National Cancer Institute (NCI), U.S.A., which provided the data using the panel of human tumor cell lines and the National Institute of Neurological Disorders and Stroke (NINDS), U.S.A. for undertaking the short-term toxicity studies in mice. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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AU - Bhullar, Khushwant S.

AU - Rupasinghe, H. P.Vasantha

AU - Balzarini, Jan

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Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors

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