Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia

Andrea de Bartolomeis; Licia Vellucci; Annarita Barone; Mirko Manchia; Vincenzo De Luca; Felice Iasevoli; Christoph U. Correll

doi:10.1016/j.pharmthera.2022.108236

Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia

Andrea de Bartolomeis, Licia Vellucci, Annarita Barone, Mirko Manchia, Vincenzo De Luca, Felice Iasevoli, Christoph U. Correll

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Original language	English
Article number	108236
Journal	Pharmacology and Therapeutics
Volume	236
DOIs	https://doi.org/10.1016/j.pharmthera.2022.108236
Publication status	Published - Aug 2022
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology (medical)
Pharmacology

Keywords

Antipsychotics
Clozapine
Immediate early genes
Postsynaptic density
Psychosis
Treatment-resistant schizophrenia

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10.1016/j.pharmthera.2022.108236

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de Bartolomeis, A., Vellucci, L., Barone, A., Manchia, M., De Luca, V., Iasevoli, F., & Correll, C. U. (2022). Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia. Pharmacology and Therapeutics, 236, Article 108236. https://doi.org/10.1016/j.pharmthera.2022.108236

Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia. / de Bartolomeis, Andrea; Vellucci, Licia; Barone, Annarita et al.
In: Pharmacology and Therapeutics, Vol. 236, 108236, 08.2022.

Research output: Contribution to journal › Review article › peer-review

de Bartolomeis, A, Vellucci, L, Barone, A, Manchia, M, De Luca, V, Iasevoli, F & Correll, CU 2022, 'Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia', Pharmacology and Therapeutics, vol. 236, 108236. https://doi.org/10.1016/j.pharmthera.2022.108236

de Bartolomeis A, Vellucci L, Barone A, Manchia M, De Luca V, Iasevoli F et al. Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia. Pharmacology and Therapeutics. 2022 Aug;236:108236. doi: 10.1016/j.pharmthera.2022.108236

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title = "Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia",

keywords = "Antipsychotics, Clozapine, Immediate early genes, Postsynaptic density, Psychosis, Treatment-resistant schizophrenia",

author = "{de Bartolomeis}, Andrea and Licia Vellucci and Annarita Barone and Mirko Manchia and {De Luca}, Vincenzo and Felice Iasevoli and Correll, {Christoph U.}",

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AU - Manchia, Mirko

AU - De Luca, Vincenzo

AU - Iasevoli, Felice

AU - Correll, Christoph U.

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Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia

ASJC Scopus Subject Areas

Keywords

Access to Document

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