Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice

John Mach; Gizem Gemikonakli; Caitlin Logan; Brent Vander Wyk; Heather Allore; Swathi Ekambareshwar; Alice E. Kane; Susan E. Howlett; Rafael de Cabo; David G. Le Couteur; Sarah N. Hilmer

doi:10.1093/gerona/glaa060

Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice

John Mach, Gizem Gemikonakli, Caitlin Logan, Brent Vander Wyk, Heather Allore, Swathi Ekambareshwar, Alice E. Kane, Susan E. Howlett, Rafael de Cabo, David G. Le Couteur, Sarah N. Hilmer

Biochemistry, Genetics and Molecular Biology

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Original language	English
Pages (from-to)	1010-1018
Number of pages	9
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	76
Issue number	6
DOIs	https://doi.org/10.1093/gerona/glaa060
Publication status	Published - Jun 1 2021

ASJC Scopus Subject Areas

Geriatrics and Gerontology
Ageing

Keywords

Deprescribing
Drug Burden Index
Frailty
Geriatric pharmacology
Polypharmacy

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10.1093/gerona/glaa060

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Mach, J., Gemikonakli, G., Logan, C., Wyk, B. V., Allore, H., Ekambareshwar, S., Kane, A. E., Howlett, S. E., de Cabo, R., Le Couteur, D. G., & Hilmer, S. N. (2021). Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 76(6), 1010-1018. https://doi.org/10.1093/gerona/glaa060

Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. / Mach, John; Gemikonakli, Gizem; Logan, Caitlin et al.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 76, No. 6, 01.06.2021, p. 1010-1018.

Research output: Contribution to journal › Article › peer-review

Mach, J, Gemikonakli, G, Logan, C, Wyk, BV, Allore, H, Ekambareshwar, S, Kane, AE, Howlett, SE, de Cabo, R, Le Couteur, DG & Hilmer, SN 2021, 'Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 76, no. 6, pp. 1010-1018. https://doi.org/10.1093/gerona/glaa060

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AU - Allore, Heather

AU - Ekambareshwar, Swathi

AU - Kane, Alice E.

AU - Howlett, Susan E.

AU - de Cabo, Rafael

AU - Le Couteur, David G.

AU - Hilmer, Sarah N.

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KW - Drug Burden Index

KW - Frailty

KW - Geriatric pharmacology

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Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice

ASJC Scopus Subject Areas

Keywords

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