Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice

John Mach, Gizem Gemikonakli, Caitlin Logan, Brent Vander Wyk, Heather Allore, Swathi Ekambareshwar, Alice E. Kane, Susan E. Howlett, Rafael de Cabo, David G. Le Couteur, Sarah N. Hilmer

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)
Original languageEnglish
Pages (from-to)1010-1018
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume76
Issue number6
DOIs
Publication statusPublished - Jun 1 2021

ASJC Scopus Subject Areas

  • Geriatrics and Gerontology
  • Ageing

Keywords

  • Deprescribing
  • Drug Burden Index
  • Frailty
  • Geriatric pharmacology
  • Polypharmacy

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