A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5′-triphosphate

Matthew J. McLeod, Norman Tran, Gregory D. McCluskey, Tom D. Gillis, Stephen L. Bearne, Todd Holyoak

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
Original languageEnglish
Article numbere4648
JournalProtein Science
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 2023

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Biology

Keywords

  • CTP synthase
  • filament-competent conformation
  • gemcitabine-5′-triphosphate binding
  • inhibition
  • metal–nucleotide complex structure

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